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KMID : 0391319910010010056
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Korean Journal of Biological Response Modifiers
1991 Volume.1 No. 1 p.56 ~ p.63
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In vivo pharmacokinetic study of exogenously administered recombinant human interleukin-2
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Kim, Jung Mogg
Chung, Te Jung/Hahm, Kyung Soo/Cho, Yang Ja
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Abstract
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The ability of recombinant human interleukin-2. (rHIL-2) has resulted in its clinical utilization both as a single agent and in combination with lymphokine-activated killer cells. However, its clinical application has been restricted by its dose-related toxicity. In this report, we have studied the serum level of rHIL-2 adminstered by intraperitoneal (ip), intravenous (iv), or intramuscular (im) route in rats or mice.
IL-2 injected ip in rats and mice was absorbed rapidly into circulation to reach peak blood level in 5 minutes, then cleared off quickly with T½ of 30 minutes. IL-2 injected iv seemed to be inactivated or eliminated almost instantly and its T½ was only 5 minutes. IL-2 availability in serum after im injection of IL-2 was so variable and low that im injection was not the appropriate way to get enough therapeutic blood concentration. Lethality test showed that 5 X 106 unit/kg of IL-2 given iv or 1.3 X 107 unit /kg given ip was fatal immediately or in 24 hours observation period.
Therefore, our study suggests that effective safe way of maintaining serum IL-2 level is via continuous ip injection rather than iv or im.
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